DNA binding studies of cationic lanthanide complexes bearing a phenanthridinium group

G. Bobba, S. D. Kean, D. Parker*, A. Beeby, G. Baker

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

27 Dyfyniadau (Scopus)

Crynodeb

The binding of tetracationic - and -europium complexes of tetraamide and triamide ligands incorporating an N-methylphenanthridinium group to calf-thymus DNA, poly(dGdC) and super-coiled plasmid DNA has been monitored by absorption, luminescence and CD difference spectroscopy. With the tetraamide complexes, preferential binding to (CG) base-pairs was signalled by pronounced hypochromism, a small red shift and substantial fluorescence quenching with a limiting base-pair complex ratio of 2 : 1, consistent with an intercalative interaction and charge neutralisation. For the triamide Eu complex, a lower base-pair : complex ratio was found and changes in the form and polarisation of the Eu emission spectrum were consistent with coordination of a nucleobase phosphate group to the hydrated Eu centre.

Iaith wreiddiolSaesneg
Tudalennau (o-i)1738-1741
Nifer y tudalennau4
CyfnodolynJournal of the Chemical Society, Perkin Transactions 2
Rhif cyhoeddi9
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Hyd 2001
Cyhoeddwyd yn allanolIe

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