Crynodeb
The binding of tetracationic - and -europium complexes of tetraamide and triamide ligands incorporating an N-methylphenanthridinium group to calf-thymus DNA, poly(dGdC) and super-coiled plasmid DNA has been monitored by absorption, luminescence and CD difference spectroscopy. With the tetraamide complexes, preferential binding to (CG) base-pairs was signalled by pronounced hypochromism, a small red shift and substantial fluorescence quenching with a limiting base-pair complex ratio of 2 : 1, consistent with an intercalative interaction and charge neutralisation. For the triamide Eu complex, a lower base-pair : complex ratio was found and changes in the form and polarisation of the Eu emission spectrum were consistent with coordination of a nucleobase phosphate group to the hydrated Eu centre.
Iaith wreiddiol | Saesneg |
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Tudalennau (o-i) | 1738-1741 |
Nifer y tudalennau | 4 |
Cyfnodolyn | Journal of the Chemical Society, Perkin Transactions 2 |
Rhif cyhoeddi | 9 |
Dynodwyr Gwrthrych Digidol (DOIs) | |
Statws | Cyhoeddwyd - 1 Hyd 2001 |
Cyhoeddwyd yn allanol | Ie |