Differential Evolution approach to detect recent admixture

Konstantin Kozlov; Dmitri Chebotarev; Mehedi Hassan; Martin Triska; Petr Triska; Pavel Flegontov; Tatiana V. Tatarinova

doi:10.1186/1471-2164-16-S8-S9

Differential Evolution approach to detect recent admixture

Konstantin Kozlov, Dmitri Chebotarev, Mehedi Hassan, Martin Triska, Petr Triska, Pavel Flegontov, Tatiana V. Tatarinova^*

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

7 Dyfyniadau (Scopus)

39 Wedi eu Llwytho i Lawr (Pure)

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The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual's knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	S9
Nifer y tudalennau	11
Cyfnodolyn	BMC Genomics
Cyfrol	16
Rhif cyhoeddi	8
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1186/1471-2164-16-S8-S9
Statws	Cyhoeddwyd - 18 Meh 2015
Cyhoeddwyd yn allanol	Ie
Digwyddiad	VarI Special Interest Group Meeting: Identification and annotation of genetic variants in the context of structure, function, and disease - John B. Hynes Memorial Convention Center, Boston, Yr Unol Daleithiau Hyd: 12 Gorff 2014 → 12 Gorff 2014

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

Mynediad at Ddogfen

10.1186/1471-2164-16-S8-S9Trwydded: CC BY

1471-2164-16-S8-S9Fersiwn derfynol wedi’i chyhoeddi, 1.04 MBTrwydded: CC BY

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@article{5f56b14df55442f4bba684dc463fa2e8,

title = "Differential Evolution approach to detect recent admixture",

abstract = "The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual's knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.",

keywords = "Admixture, Ancestry prediction, Differential evolution, Geographical origin",

author = "Konstantin Kozlov and Dmitri Chebotarev and Mehedi Hassan and Martin Triska and Petr Triska and Pavel Flegontov and Tatarinova, {Tatiana V.}",

year = "2015",

month = jun,

day = "18",

doi = "10.1186/1471-2164-16-S8-S9",

language = "English",

volume = "16",

journal = "BMC Genomics",

issn = "1471-2164",

publisher = "Springer",

number = "8",

note = "VarI Special Interest Group Meeting : Identification and annotation of genetic variants in the context of structure, function, and disease, VarI-SIG ; Conference date: 12-07-2014 Through 12-07-2014",

}

TY - JOUR

T1 - Differential Evolution approach to detect recent admixture

AU - Kozlov, Konstantin

AU - Chebotarev, Dmitri

AU - Hassan, Mehedi

AU - Triska, Martin

AU - Triska, Petr

AU - Flegontov, Pavel

AU - Tatarinova, Tatiana V.

PY - 2015/6/18

Y1 - 2015/6/18

N2 - The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual's knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.

AB - The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual's knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.

KW - Admixture

KW - Ancestry prediction

KW - Differential evolution

KW - Geographical origin

U2 - 10.1186/1471-2164-16-S8-S9

DO - 10.1186/1471-2164-16-S8-S9

M3 - Article

C2 - 26111206

AN - SCOPUS:84969584485

SN - 1471-2164

VL - 16

JO - BMC Genomics

JF - BMC Genomics

IS - 8

M1 - S9

T2 - VarI Special Interest Group Meeting

Y2 - 12 July 2014 through 12 July 2014

ER -

Differential Evolution approach to detect recent admixture

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