Differential Evolution approach to detect recent admixture

Konstantin Kozlov, Dmitri Chebotarev, Mehedi Hassan, Martin Triska, Petr Triska, Pavel Flegontov, Tatiana V. Tatarinova*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

7 Dyfyniadau (Scopus)
31 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual's knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.

Iaith wreiddiolSaesneg
Rhif yr erthyglS9
Nifer y tudalennau11
CyfnodolynBMC Genomics
Cyfrol16
Rhif cyhoeddi8
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 18 Meh 2015
Cyhoeddwyd yn allanolIe
DigwyddiadVarI Special Interest Group Meeting: Identification and annotation of genetic variants in the context of structure, function, and disease - John B. Hynes Memorial Convention Center, Boston, Yr Unol Daleithiau
Hyd: 12 Gorff 201412 Gorff 2014

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