Concussion history in rugby union players is associated with depressed cerebrovascular reactivity and cognition

Thomas Owens, Thomas A. Calverley, Benjamin Stacey, George Rose, Lewis Fall, Hayato Tsukamoto, Gareth Jones , Robin Corkill, Edouard Tuaillon, Christophe Hirtz, Sylvain Lehmann, Nicola Marchi, Christopher Marley, Damian Bailey

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

Crynodeb

Recurrent contact and concussion in rugby union remains a significant public health concern given the potential increased risk of neurodegeneration in later life. This study determined to what extent prior-recurrent contact impacts molecular-hemodynamic biomarkers underpinning cognition in current professional rugby union players with a history of concussion. Measurements were performed in 20 professional rugby union players with an average of 16 (interquartile range [IQR] 13-19) years playing history reporting 3 (IQR 1-4) concussions. They were compared to 17 sex-age-physical activity-and education-matched non-contact controls with no prior history of self-reported concussion. Venous blood was assayed directly for the ascorbate free radical (A•- electron paramagnetic resonance spectroscopy) nitric oxide metabolites (NO reductive ozone-based chemiluminescence) and select biomarkers of neurovascular unit integrity (NVU chemiluminescence/ELISA). Middle cerebral artery blood flow velocity (MCAv doppler ultrasound) was employed to determine basal perfusion and cerebrovascular reactivity (CVR) to hyper/hypocapnia ( CVRCO2Hyper/Hypo). Cognition was assessed by neuropsychometric testing. Elevated systemic oxidative-nitrosative stress was confirmed in the players through increased A•- (p < 0.001) and suppression of NO bioavailability (p < 0.001). This was accompanied by a lower CVR range (
CVRCO2Range; p = 0.045) elevation in neurofilament light-chain (p = 0.010) and frontotemporal impairments in immediate-memory (p = 0.001) delayed-recall (p = 0.048) and fine-motor coordination (p < 0.001). Accelerated cognitive decline subsequent to prior-recurrent contact and concussion history is associated with a free radical-mediated suppression of CVR and neuronal injury providing important mechanistic insight that may help better inform clinical management.
Iaith wreiddiolSaesneg
Rhif yr erthygl14046
Tudalennau (o-i)2291-2299
CyfnodolynScandinavian Journal of Medicine and Science in Sports
Cyfrol31
Rhif cyhoeddi12
Dyddiad ar-lein cynnar6 Medi 2021
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 3 Rhag 2021

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