Choline acetyltransferase-like immunoreactivity in small diameter neurones of the rat dorsal root ganglion

Holger Sann; Peter W. McCarthy; Michael Mäder; Michael Schemann

doi:10.1016/0304-3940(95)11951-R

Choline acetyltransferase-like immunoreactivity in small diameter neurones of the rat dorsal root ganglion

Holger Sann, Peter W. McCarthy, Michael Mäder, Michael Schemann

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In the rat choline acetyltransferase (ChAT)-like immunoreactivity (ChAT-LI) was demonstrated in the dorsal root ganglion (DRG), in the superficial spinal cord and in the subepithelial layer of the ureter using immunohistochemical techniques. In the L1 DRG, 66% of the neurones were ChAT-LI. They did not express neurofilament immunoreactivity (RT97 negative) but could also contain calcitonin gene-related peptide-like immunoreactivity (CGRP-LI). In the superficial spinal cord and in the subepithelial plexus of the ureter - both areas where high numbers of fine afferent fibres have been demonstrated - CGRP-LI and ChAT-LI were co-distributed, indicating that ChAT can be found in the peripheral and central endings of small afferents. The data provide morphological evidence that a substantial proportion of afferent fibres are cholinergic.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	17-20
Nifer y tudalennau	4
Cyfnodolyn	Neuroscience Letters
Cyfrol	198
Rhif cyhoeddi	1
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/0304-3940(95)11951-R
Statws	Cyhoeddwyd - 22 Medi 1995

Mynediad at Ddogfen

10.1016/0304-3940(95)11951-RTrwydded: CC BY-NC-ND

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@article{6b40a905edf6499cbc33e412d4b3a013,

title = "Choline acetyltransferase-like immunoreactivity in small diameter neurones of the rat dorsal root ganglion",

abstract = "In the rat choline acetyltransferase (ChAT)-like immunoreactivity (ChAT-LI) was demonstrated in the dorsal root ganglion (DRG), in the superficial spinal cord and in the subepithelial layer of the ureter using immunohistochemical techniques. In the L1 DRG, 66% of the neurones were ChAT-LI. They did not express neurofilament immunoreactivity (RT97 negative) but could also contain calcitonin gene-related peptide-like immunoreactivity (CGRP-LI). In the superficial spinal cord and in the subepithelial plexus of the ureter - both areas where high numbers of fine afferent fibres have been demonstrated - CGRP-LI and ChAT-LI were co-distributed, indicating that ChAT can be found in the peripheral and central endings of small afferents. The data provide morphological evidence that a substantial proportion of afferent fibres are cholinergic.",

keywords = "Calcitonin gene-related peptide, Choline acetyltransferase, Dorsal root ganglion, Rat, Spinal cord, Ureter",

author = "Holger Sann and McCarthy, {Peter W.} and Michael M{\"a}der and Michael Schemann",

year = "1995",

month = sep,

day = "22",

doi = "10.1016/0304-3940(95)11951-R",

language = "English",

volume = "198",

pages = "17--20",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Choline acetyltransferase-like immunoreactivity in small diameter neurones of the rat dorsal root ganglion

AU - Sann, Holger

AU - McCarthy, Peter W.

AU - Mäder, Michael

AU - Schemann, Michael

PY - 1995/9/22

Y1 - 1995/9/22

N2 - In the rat choline acetyltransferase (ChAT)-like immunoreactivity (ChAT-LI) was demonstrated in the dorsal root ganglion (DRG), in the superficial spinal cord and in the subepithelial layer of the ureter using immunohistochemical techniques. In the L1 DRG, 66% of the neurones were ChAT-LI. They did not express neurofilament immunoreactivity (RT97 negative) but could also contain calcitonin gene-related peptide-like immunoreactivity (CGRP-LI). In the superficial spinal cord and in the subepithelial plexus of the ureter - both areas where high numbers of fine afferent fibres have been demonstrated - CGRP-LI and ChAT-LI were co-distributed, indicating that ChAT can be found in the peripheral and central endings of small afferents. The data provide morphological evidence that a substantial proportion of afferent fibres are cholinergic.

AB - In the rat choline acetyltransferase (ChAT)-like immunoreactivity (ChAT-LI) was demonstrated in the dorsal root ganglion (DRG), in the superficial spinal cord and in the subepithelial layer of the ureter using immunohistochemical techniques. In the L1 DRG, 66% of the neurones were ChAT-LI. They did not express neurofilament immunoreactivity (RT97 negative) but could also contain calcitonin gene-related peptide-like immunoreactivity (CGRP-LI). In the superficial spinal cord and in the subepithelial plexus of the ureter - both areas where high numbers of fine afferent fibres have been demonstrated - CGRP-LI and ChAT-LI were co-distributed, indicating that ChAT can be found in the peripheral and central endings of small afferents. The data provide morphological evidence that a substantial proportion of afferent fibres are cholinergic.

KW - Calcitonin gene-related peptide

KW - Choline acetyltransferase

KW - Dorsal root ganglion

KW - Rat

KW - Spinal cord

KW - Ureter

U2 - 10.1016/0304-3940(95)11951-R

DO - 10.1016/0304-3940(95)11951-R

M3 - Article

C2 - 8570086

AN - SCOPUS:0029117807

VL - 198

SP - 17

EP - 20

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -

Choline acetyltransferase-like immunoreactivity in small diameter neurones of the rat dorsal root ganglion

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