Base-free selective oxidation of glycerol has been investigated using trimetallic Au-Pd-Pt nanoparticles supported on titania and their corresponding bimetallic catalysts. Catalysts were prepared by the sol-immobilization method and characterized by means of TEM, UV/Vis spectroscopy, diffuse reflectance infrared fourier transform spectroscopy, X-ray photoelectron spectroscopy, and microwave plasma-atomic emission spectroscopy. It was found that of the bimetallic catalysts, Pd-Pt/TiO2 was the most active with high selectivity to C3 products. The addition of Au to this catalyst to form the trimetallic Au-Pd-Pt/TiO2, resulted in an increase in activity relative to Pd-Pt/TiO2. The turnover frequency increased from 210 h-1 with the Pd-Pt/TiO2 catalyst to378 h -1 for the trimetallic Au-Pd-Pt/TiO2 catalyst with retention of selectivity towards C3 products. The noble trio: Base-free selective oxidation of glycerol is investigated using trimetallic Au-Pd-Pt nanoparticles supported on titania and their corresponding bimetallic catalysts. Increased activity is observed for the trimetallic Au-Pd-Pt/TiO 2 catalyst, with retention of selectivity towards C3 products.