Aromatic homolytic substitution using solid phase synthesis

Steven M. Allin, W. Russell Bowman, Rehana Karim, Shahzad S. Rahman

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

    Crynodeb

    Solid phase synthesis has been used to carry out intramolecular aromatic homolytic substitution with benzoimidazole precursors. The protocol attaches the radical precursors to the resins via the radical leaving groups (in the aromatic homolytic substitution). When the radical reactions are complete, the leaving group, unaltered starting material and reduced uncylised products remain attached to the resin, which facilitates easy separation of the cyclised products. Novel use of focussed microwave irradiation in solid phase radical reactions drastically shortens the reactions times. Tributylgermanium hydride has been used to replace the toxic and troublesome tributyltin hydride in the radical reactions.

    Solid phase synthesis has been used to carry out intramolecular aromatic homolytic substitution with benzoimidazole precursors.
    Iaith wreiddiolSaesneg
    Tudalennau (o-i)4306-4316
    CyfnodolynTetrahedron Letters
    Cyfrol62
    Rhif cyhoeddi18
    Dynodwyr Gwrthrych Digidol (DOIs)
    StatwsCyhoeddwyd - 1 Mai 2006

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