Analysis of Tidal Breathing Profiles in Cystic Fibrosis and COPD

Edgar Williams, Ric L. Colasanti, M. Jocelyn Morris, Richard G. Madgwick, Linda Sutton

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid


Abstract Study objectives: To explore the flow and time domain characteristics of resting tidal airflow profiles in the presence of obstructive airway disease. Methods: Spirometry was performed on 81 adults and 46 juveniles in the lung function laboratory. All the juveniles had cystic fibrosis (CF), as did some of the adults (n = 25), with the remainder having either healthy lungs or COPD. Resting breathing profiles were recorded using a pneumotachograph. Thirteen flow and time domain parameters were extracted from each profile. Two new indexes were derived that are influenced by the shape of the post-peak expiratory flow portion of the expirogram. In this expirogram, the first index (change in post-peak expiratory flow at time 20% [Tppef20]) describes early changes in post-peak flow, while the second index (change in post-peak expiratory flow at time 80% [Tppef80]) describes later changes in flow. Multiple linear regression techniques were used to define the relationship between body size, flow and time domain parameters, and FEV1, a measure of obstructive airway disease. Results: In juvenile subjects with CF, body weight and the time to reach peak expiratory flow are the main correlates with FEV1 (adjusted r2 = 0.74). The adult CF group are different with the expiratory flow index (Tppef20) being the major correlate with FEV1 (adjusted r2 = 0.77). In the COPD group, the second expiratory flow index (Tppef80) is the major correlate instead (adjusted r2 = 0.6). Conclusions: Using multiple linear regression techniques has allowed the description of the interrelationships between body size, age, and tidal breathing profile in obstructive airway disease. The relationship between the flow indexes Tppef20 and Tppef80 show that in adults with CF, the loss of expiratory flow braking is an important adaptation to disease, while in COPD pulmonary hyperinflation is the predominant factor. expiratory flow braking FEV1 lung function pulmonary hyperinflation Footnotes Abbreviations: CF = cystic fibrosis; MLR = multiple linear regression; PEF = peak expiratory flow; PIF = peak inspiratory flow; Tppef20 = change in post-peak expiratory flow at time 20%; Tppef80 = change in post-peak expiratory flow at time 80%; Tptef = time from the onset of expiration to peak expiratory flow; Tptif = time from the onset of inspiration to
Iaith wreiddiolSaesneg
Tudalennau (o-i)901 - 908
Nifer y tudalennau7
CyfnodolynCHEST (Official publication of the American College of Chest Physicians)
Rhif cyhoeddi3
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Maw 2004

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'Analysis of Tidal Breathing Profiles in Cystic Fibrosis and COPD'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

Dyfynnu hyn