A scalable and expedient route to 1- azahelicene derivatives and its subsequent application to a chiral-relay asymmetric strategy

Marko Weiner; Rosenildo  Da Costa; Fu-Howe Lee; Matthew Fuchter

doi:10.1021/ol400493x

A scalable and expedient route to 1- azahelicene derivatives and its subsequent application to a chiral-relay asymmetric strategy

Marko Weiner, Rosenildo Da Costa, Fu-Howe Lee, Matthew Fuchter

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

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A rapid route to diversely functionalized 1-aza[6]helicenes has been achieved via the development of a copper-mediated cross-coupling reaction, followed by PtCl4-catalyzed cycloisomerization. Not only does this method allow access to these functionally important molecules on gram scale, but this strategy is also suitable for relaying the axial chirality of a key intermediate to the helicity of the product.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	1706-1709
Nifer y tudalennau	4
Cyfnodolyn	Organic Letters
Cyfrol	15
Rhif cyhoeddi	7
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1021/ol400493x
Statws	Cyhoeddwyd - 2013

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10.1021/ol400493x

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@article{993a02d7ebf24a9099a9270587968dd6,

title = "A scalable and expedient route to 1- azahelicene derivatives and its subsequent application to a chiral-relay asymmetric strategy",

abstract = "A rapid route to diversely functionalized 1-aza[6]helicenes has been achieved via the development of a copper-mediated cross-coupling reaction, followed by PtCl4-catalyzed cycloisomerization. Not only does this method allow access to these functionally important molecules on gram scale, but this strategy is also suitable for relaying the axial chirality of a key intermediate to the helicity of the product.",

author = "Marko Weiner and {Da Costa}, Rosenildo and Fu-Howe Lee and Matthew Fuchter",

year = "2013",

doi = "10.1021/ol400493x",

language = "English",

volume = "15",

pages = "1706--1709",

journal = "Organic Letters",

issn = "1523-7052",

publisher = "American Chemical Society",

number = "7",

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TY - JOUR

T1 - A scalable and expedient route to 1- azahelicene derivatives and its subsequent application to a chiral-relay asymmetric strategy

AU - Weiner, Marko

AU - Da Costa, Rosenildo

AU - Lee, Fu-Howe

AU - Fuchter, Matthew

PY - 2013

Y1 - 2013

N2 - A rapid route to diversely functionalized 1-aza[6]helicenes has been achieved via the development of a copper-mediated cross-coupling reaction, followed by PtCl4-catalyzed cycloisomerization. Not only does this method allow access to these functionally important molecules on gram scale, but this strategy is also suitable for relaying the axial chirality of a key intermediate to the helicity of the product.

AB - A rapid route to diversely functionalized 1-aza[6]helicenes has been achieved via the development of a copper-mediated cross-coupling reaction, followed by PtCl4-catalyzed cycloisomerization. Not only does this method allow access to these functionally important molecules on gram scale, but this strategy is also suitable for relaying the axial chirality of a key intermediate to the helicity of the product.

U2 - 10.1021/ol400493x

DO - 10.1021/ol400493x

M3 - Article

SN - 1523-7052

VL - 15

SP - 1706

EP - 1709

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

A scalable and expedient route to 1- azahelicene derivatives and its subsequent application to a chiral-relay asymmetric strategy

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