A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis

Philip C. Bulman Page; Andrew E. Graham; B. Kevin Park

doi:10.1016/S0040-4020(01)88265-X

A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis

Philip C. Bulman Page^*, Andrew E. Graham, B. Kevin Park

^*Awdur cyfatebol y gwaith hwn

Cyfadran Cyfrifiadureg, Peirianneg a Gwyddoniaeth

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

22 Dyfyniadau (Scopus)

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1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	7265-7274
Nifer y tudalennau	10
Cyfnodolyn	Tetrahedron Letters
Cyfrol	48
Rhif cyhoeddi	35
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/S0040-4020(01)88265-X
Statws	Cyhoeddwyd - 1992

Mynediad at Ddogfen

10.1016/S0040-4020(01)88265-XTrwydded: Amhenodol

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@article{d75e03ab245f42b797247466a4cf3fc7,

title = "A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis",

abstract = "1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux. ",

author = "{Bulman Page}, {Philip C.} and Graham, {Andrew E.} and Park, {B. Kevin}",

year = "1992",

doi = "10.1016/S0040-4020(01)88265-X",

language = "English",

volume = "48",

pages = "7265--7274",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "35",

}

TY - JOUR

T1 - A convenient preparation of symmetrical and unsymmetrical 1,2-diketones

T2 - application to fluorinated phenytoin synthesis

AU - Bulman Page, Philip C.

AU - Graham, Andrew E.

AU - Park, B. Kevin

PY - 1992

Y1 - 1992

N2 - 1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux.

AB - 1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux.

U2 - 10.1016/S0040-4020(01)88265-X

DO - 10.1016/S0040-4020(01)88265-X

M3 - Article

AN - SCOPUS:0026703228

VL - 48

SP - 7265

EP - 7274

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 35

ER -

A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis

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Mynediad at Ddogfen

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